About the Project
The PhD project would be to investigate the role of the mRNA capping enzymes in embryonic stem cell pluripotency and differentiation. Which genes do the capping enzymes control? What is the impact of the capping enzymes on embryonic stem cell differentiation? Should the capping enzymes be considered as therapeutic targets?
The student will be investigating T cell differentiation and function, and analysing transcription and translation using next generation sequencing and mass spectrometry. The student will work within the laboratories of Victoria Cowling and Greg Findlay, integrated in the Centre for Gene Expression and MRC Protein Phosphorylation Unit, at the University of Dundee
Varshney D, Lombardi O, Schweikert G, Dunn S, Suska O and Cowling VH (2018) mRNA cap methyltransferase (RNMT-RAM) is required for RNA pol II-dependent transcription Cell Rep. 2018 May 1;23(5):1530-1542. doi: 10.1016/j.celrep.2018.04.004 PMID: 29719263
Aregger M, Kaskar A, Fernandez-Sanchez ME, Simone Weidlich S and Cowling VH (2016) CDK1-cyclinB activates RNMT co-ordinating mRNA cap methylation with G1 phase transcription Molecular Cell 2016 Mar 3;61(5):734-46. doi: 10.1016/j.molcel.2016.02.008 PMID: 26942677
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