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MRC Integrative-Toxicology Training Partnership (ITTP) PhD Studentship Identification of molecular mechanisms of late-occurring cardiotoxicity induced by oncology therapeutics


Translational and Clinical Research Institute

About the Project

Number of awards
1

Start date and duration:
October 2020 for 4 years.

Overview:
Cardiotoxicity is a major complication of cancer chemotherapy, both an acute and frequently late-onset toxicity, occurring months/years after chemotherapy. A toxicity mechanism involving perturbations to cellular/tissue structure is implied, but not yet proven. The aim of this project is to determine this toxicological mechanism using in vitro studies. However, this is limited by a lack of qualified cell models for in vitro studies and the clinical applicability of such models. Consequently, an objective of this project is development of reliable in vitro multicellular cardiac models with capability for longer-term assessment of drug-induced cardiotoxicity. The project will then use these models to determine the toxicological mechanism, which will inform management of chemotherapy-induced cardiotoxicities and improved cancer treatment.

Training will be provided in standard cell, molecular biology and toxicology methodologies, development of in vitro cardiac cell models, and novel state-of-the-art toxicological methodologies and technologies. Additionally, bespoke courses on research skills, communication skills, teamworking, and career management will be provided. The student will also attend an annual residential course with other MRC ITTP students, hosted by the MRC Toxicology Unit.

Sponsor:
MRC Integrative Toxicology Training Partnership (ITTP), managed through the MRC Toxicology Unit at the University of Cambridge (https://www.mrc-tox.cam.ac.uk/)

Name of supervisor(s):
Newcastle University
Primary Supervisor:
Dr Jason Gill (https://bit.ly/36jrxUL), School of Pharmacy and Translational and Clinical Research Institute.
Second Supervisor:
Dr Gavin Richardson (https://bit.ly/3cUdnMv), Biosciences Institute.
University of Liverpool
Third Supervisor::
Dr Parveen Sharma (https://www.liverpool.ac.uk/translational-medicine/staff/parveen-sharma/), MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology.

Eligibility Criteria:
You must have, or expect to achieve at least a 2:1 Honours degree in a pharmacology, cell biology, toxicology or related discipline. A further qualification such as an MSc or MRes in a relevant subject is advantageous.
The award is available to UK/EU applicants only.

How to apply:
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’ (https://bit.ly/3cVYitF).
Only mandatory fields need to be completed. However, you will need to include the following information:
• insert the programme code 8300F in the programme of study section
• select ‘PhD in the Faculty of Medical Sciences – Toxicology’ as the programme of study
• insert the studentship code TC010 in the studentship/partnership reference field
• attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code TC010 and state how your interests and experience relate to the project
• attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.

Contact:
For further details, please email:
Dr J Gill (https://bit.ly/36jrxUL)
School of Pharmacy and Translational and Clinical Research Institute

Funding Notes

This award covers UK/EU tuition fees, student stipend at MRC rates (currently £15,285 per annum) and contribution towards project research costs.

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