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MRC Precision Medicine DTP: A collaborative systems biology-based approach to dissect novel mechanisms of cardiovascular disease

Project Description

Prof Christian Delles
Prof Stuart Nicklin
Dr Simon Rogers

PhD project summary:
Cardiovascular diseases (CVD) are the major cause of morbidity and mortality worldwide. Whilst some of the key mechanisms of the development of CVD are firmly established the interplay of such mechanisms and the contribution of additional, yet unknown pathophysiological principles is subject to ongoing research. We propose a project that will address this gap in knowledge by employing an interdisciplinary (cardiovascular research / computing science) and translational (preclinical / clinical) approach using systems biology methods. We have generated complex omics datasets in a range of preclinical models and clinical cohorts with cardiovascular diseases that will form the basis for in-depth analysis within this project. Whilst this proposal will train the successful candidate in systems biology and bioinformatics techniques it will be firmly embedded in our active research groups addressing mechanistic and clinical questions in CVD. As such we are reaching out to candidates with a background in statistics, mathematics or computing science who are interested in cross-disciplinary training that will include basic wet lab and clinical research techniques. The project will compare rodent and human datasets and dissect concordant and discordant molecular features that will be subject to further validation and, in the longer term, development of therapeutic approaches.

This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location:

Please note, you must apply to one of the projects and you should contact the primary supervisor prior to making your application. Additional information on the application process is available from the links below.

For more information about Precision Medicine visit:

Main programme page:

Funding Notes

Start: September 2019

Qualifications criteria: Applicants applying for a MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualifications, in an appropriate science/technology area.

Residence criteria: The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £14,777 (RCUK rate 2018/19) for UK and EU nationals that meet all required eligibility criteria.

Full eligibility details are available: View Website

Enquiries regarding programme:

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