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MRC Precision Medicine DTP: Defining Plasmodium falciparum interactions in the bone marrow

  • Full or part time

    Dr A Rowe
  • Application Deadline
    Monday, January 07, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Supervisors:
Prof Matthias Marti
Dr Alex Rowe
Dr Thomas Otto

PhD project summary:
Malaria remains a major global health threat, despite continuous elimination efforts. The human malaria parasite, Plasmodium falciparum can infect a large proportion of red blood cells and sequester in the vasculature of various organs, resulting in various complications including severe disease and death. We have recently identified the bone marrow niche as a major reservoir for P. falciparum and other parasites including the rodent model P. berghei. This project involves supervision from experts in parasite biology, transcriptomics and clinical malaria. In this project the PhD candidate will define the parasite host interactions underlying parasite sequestration in the bone marrow niche, using a combination of state-of-the-art in vivo and in vitro studies (e.g., various microscopy techniques, single cell transcriptomics etc), including a research visit to Malawi to study material from malaria patients. The findings will shed light on an as yet uncharacterized part of the parasite cycle and provide a basis for novel intervention strategies. The student will work with an interdisciplinary team and learn both wet lab and computational methods to prepare him/her for a future in precision medicine.
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This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location:

http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919

Please note, you must apply to one of the projects and you should contact the primary supervisor prior to making your application. Additional information on the application process is available from the links below.

For more information about Precision Medicine visit:

https://www.gla.ac.uk/colleges/mvls/graduateschool/precisionmedicine/

Main programme page: http://www.ed.ac.uk/usher/precision-medicine

Funding Notes

Start: September 2019

Qualifications criteria: Applicants applying for a MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualifications, in an appropriate science/technology area.

Residence criteria: The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £14,777 (RCUK rate 2018/19) for UK and EU nationals that meet all required eligibility criteria.

Full eligibility details are available: View Website

Enquiries regarding programme:

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