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MRC Precision Medicine DTP: Genomic Surveillance to guide Rabies Elimination

  • Full or part time

    Prof A Rambaut
  • Application Deadline
    Monday, January 07, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Supervisors:
Dr Katie Hampson
Prof Andrew Rambaut
Dr Roman Biek

PhD project summary:
Rabies kills thousands of people around the world every year but a global target has now been set to eliminate human deaths from dog-mediated rabies by 2030 and large-scale mass dog vaccination programmes are being undertaken around the world working towards this aim. Extensive genomics and bioinformatics research has generated valuable insights into the diversity, emergence and spread of rabies viruses. Building on this background, this PhD will investigate how genomic data can be incorporated into surveillance to inform rabies elimination programmes. A new data-centric bioinformatics platform will be used to consolidate and curate publically available rabies sequences and new sequence data from across settings in sub-Saharan Africa and Southeast Asia through an extended collaborative network. Circulating viral diversity will be quantified and the RABV distribution characterized, to identify gaps in need of improved surveillance. Robust genomic metrics will be developed to measure progress made towards rabies elimination. The project will focus on developing tools to support the endgame including variant discrimination, revealing undetected transmission, identifying sources of incursions and visualizing and communicating insights from genomic surveillance to policymakers, practitioners and the general public to inform control.
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This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location:

http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919

Please note, you must apply to one of the projects and you should contact the primary supervisor prior to making your application. Additional information on the application process is available from the links below.

For more information about Precision Medicine visit:

https://www.gla.ac.uk/colleges/mvls/graduateschool/precisionmedicine/

Main programme page: http://www.ed.ac.uk/usher/precision-medicine

Funding Notes

Start: September 2019

Qualifications criteria: Applicants applying for a MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualifications, in an appropriate science/technology area.

Residence criteria: The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £14,777 (RCUK rate 2018/19) for UK and EU nationals that meet all required eligibility criteria.

Full eligibility details are available: View Website

Enquiries regarding programme:

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