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MRC Precision Medicine DTP: Omics based strategies for precision medicine in hypertension and cardiovascular disease

Project Description

Prof Eleanor Davies
Dr Scott MacKenzie

Project summary:
This project will utilize a systems biology "-omics" approach to improve diagnosis of endocrine forms of hypertension while also investigating the role of microRNAs in the development of these conditions. Up to 15% of hypertension has an endocrine cause resulting from excessive hormone production and leading to a range of co-morbidities that include stroke, heart failure, atrial fibrillation, left ventricular hypertrophy and obesity. While endocrine hypertension is readily treatable, its accurate diagnosis is time-consuming and costly, which delays the administration of appropriate treatment. We are currently part of a large international study tasked with using circulating microRNA profiles to improve diagnosis of endocrine hypertension by analyzing a large cohort of carefully-phenotyped human subjects with endocrine hypertension ( MicroRNAs are regulatory non-coding RNAs that are also released by tissues into the bloodstream where they circulate in a stable, cell-free form, and can act as relatively stable and accessible biomarkers for specific disease states. Circulating microRNAs that associate with forms of endocrine hypertension are also likely to provide insights into the underlying pathophysiological mechanisms of these conditions. The identification and investigation of these microRNAs will form the core of this highly important and timely research project.

This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location. Please note that your application along with any supporting documents will be shared between both the University of Edinburgh and Glasgow.

For information on ‘How to Apply’ is detailed here:
Please note that all applications must be submitted via the University of Edinburgh:

Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available from the link above.

For more information about Precision Medicine visit:

Funding Notes

Start: September 2020

Qualifications criteria: Applicants applying for a MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualification, in an appropriate science/technology area.

Residence criteria: The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £15,009 (RCUK rate 2019/20) for UK and EU nationals that meet all required eligibility criteria.

Full eligibility details are available: View Website

Enquiries regarding programme:

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