Project summary:
Cancer is the leading cause of death for children and young adolescents, and despite improvements in survival, leukaemia accounts for about a quarter of these deaths. Paediatric Acute Lymphoblastic Leukemia (pALL) is the most common childhood cancer. Maintenance therapy with intensive multi-agent chemotherapy is currently not personalized, and lasts 2-3 years. Even if cured, many survivors have significant treatment side-effects resulting in late mortality, poor quality of life and accompanying health and societal impacts. Hence, there is an urgent need to develop more effective, and less toxic treatments for childhood ALL.
With this interdisciplinary project, we will study how the microbiome changes during pALL progression. We will use in vitro experiments to identify which microbiome-derived metabolites can affect and predict response to chemotherapy. Ultimately, we will employ advanced preclinical mouse models of pALL to modulate the microbiome to reduce disease progression and improve therapy efficacy
Project Q&A Session
Friday 2nd December, 1030 hrs.
ZOOM Meeting
https://uofglasgow.zoom.us/j/88120410579?pwd=UlZCcUpSM0VHVHlsR0x4bUdRUnV0dz09
Email: [Email Address Removed] for password information.
Funding Notes
Start: September 2023
Qualifications criteria: Applicants applying for an MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualification, in an appropriate science/technology area. The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £17,668 (UKRI rate 2022/23).
Full eligibility details are available: http://www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/
Enquiries regarding programme: [Email Address Removed]
About the Programme
This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.
All applications should be made via the University of Edinburgh, irrespective of project location. For those applying to a University of Glasgow project, your application along with any supporting documents will be shared with University of Glasgow.
How to Apply: https://www.gla.ac.uk/colleges/mvls/graduateschool/mrcdtpprecisionmedicine/howtoapply/
Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available here: http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919
For more information about Precision Medicine visit:
http://www.ed.ac.uk/usher/precision-medicine
Application Enquiries
Alexis Merry
[Email Address Removed]
Continue with Facebook
