Project summary:
Cerebral malaria is the deadliest complication of malaria caused by Plasmodium falciparum. P. falciparum infects red blood cells that stick to blood vessels in the brain, leading to fluid leak–“Blood-brain-barrier (BBB) breakdown” and potentially fatal brain swelling. Identifying the cause of BBB breakdown is key to identifying new treatments but has been elusive using prior approaches. Rapid advances in spatial biology including spatial transcriptomics and multiplex imaging techniques have enabled a step-change in our understanding of such complex biological processes. We will employ these spatial techniques on an archival collection of post-mortem cerebral malaria samples to characterise in unprecedented detail what individual cells in the brain are doing and how they are interacting with other cells and with the parasite – enabling prediction of series of events leading to BBB-breakdown. We will then use a cell culture model to validate these findings and test potential treatments. These data will provide vital steps to identify treatments that prevent BBB-barrier breakdown and improve outcome in patients.
Project Q&A Session
Monday 5th December, 1400 hrs
ZOOM Meeting:
https://uofglasgow.zoom.us/j/84945028511?pwd=T0FTWVVNK3U2MnhCNXJGbmdOS05xQT09
Email: [Email Address Removed] for password information.
About the Programme
This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.
All applications should be made via the University of Edinburgh, irrespective of project location. For those applying to a University of Glasgow project, your application along with any supporting documents will be shared with University of Glasgow.
How to Apply: https://www.gla.ac.uk/colleges/mvls/graduateschool/mrcdtpprecisionmedicine/howtoapply/
Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available here: http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919
For more information about Precision Medicine visit:
http://www.ed.ac.uk/usher/precision-medicine
Application Enquiries
Alexis Merry
[Email Address Removed]
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