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MRC Precision Medicine: VascuSenS – A platform for active self-reporting implantables for cardiovascular disease


   College of Medical, Veterinary and Life Sciences

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  Dr J Mercer  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Project summary:

Cardiovascular disease (CVD) is the single most significant medical, social and financial problem, both in Scotland and across the globe, with one third of global mortality attributable to vascular complications (WHO Stats 2022). These include the majority of heart attacks, strokes and loss of central vascular access (BHF, Heart UK), essential for chronic kidney disease patients requiring renal dialysis (Kidney Research, UK), but also for the delivery of chemotherapy drugs for cancer patients (Cancer Research UK).

Patient care can be significantly improved by integrating electrical biosensors into existing medical devices to report on vascular status, such as blockages and blood clots. Our group have devised active vascular implants that can wirelessly detect biological conditions in real-time. Not only does this provide an alert for patients and clinicians but also offers the potential to detect and treat the very earliest signs of disease, thereby avoid costly inventions. To achieve this high throughput, testing of cell/sensor interactions is required. The successful candidate will be trained in the latest bioengineering techniques, devise new labware systems of quantitating cell sensor interactions that directly lead to preclinical testing of our devices. They will contribute to developing new understanding and advancing our technology. Not only finding new ways to miniaturise and integrate the sensors to appropriate 2D and 3D devices but also understanding their interactions with biological materials. Detecting and treating restenosis and blot clots would be transformative to healthcare and would significantly reduce clinical complications, inpatient stays, follow-up and repeat interventions by stratifying the patient cohort.

About the Programme

This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location. For those applying to a University of Glasgow project, your application along with any supporting documents will be shared with University of Glasgow.

How to Apply: https://www.gla.ac.uk/colleges/mvls/graduateschool/mrcdtpprecisionmedicine/howtoapply/

Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available here: http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919

For more information about Precision Medicine visit:

http://www.ed.ac.uk/usher/precision-medicine

Application Enquiries

Alexis Merry

[Email Address Removed]


Funding Notes

Start: September 2023

Qualifications criteria: Applicants applying for an MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualification, in an appropriate science/technology area. The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £17,668 (UKRI rate 2022/23).

Full eligibility details are available: http://www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/

Enquiries regarding programme: [Email Address Removed]
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