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MRes project - Implementation of an anatomical bioreactor for tendon to bone tissue engineering applications


   College of Medicine and Veterinary Medicine


About the Project

Tendon-to-bone repair is an exciting and vital area of orthopaedic tissue engineering. While native tendon-to-bone interfaces (entheses) have a graded and highly ordered microanatomy, injury to this area often leads to poor healing, unsatisfactory repair and further problems for affected patients.

Our research group is interested in tissue-engineering of in vitro models of tendon-to-bone repair and have established an anatomical model of the enthesis in the laboratory. With our collaborators at the University of Dundee (Dr Jan Vorstius' group), we have designed and manufactured an anatomical bioreactor to impart mechanical loading on the model during formation. We expect this to greatly enhance the properties of the in vitro model and develop a reproducible platform to study enthesis repair.

This 1 year Masters by Research project will involve the following techniques:

  • 2D cell culture
  • 3D cell culture
  • Scaffold production
  • Bioreactor operation
  • Histology
  • Imaging

The candidate will be expected to have prior experience in either Biomedical Engineering or Cell/Tissue culture.

This is currently a position for self-funded candidates only. For more information or an informal chat, please email

For information on the research group, please visit the following pages;

www.paxtonlab.co.uk

https://www.ed.ac.uk/biomedical-sciences/anatomy/staff/anatomyteachingstaff/jenniferpaxton

https://www.ed.ac.uk/discovery-brain-sciences/our-staff/research-groups/jennifer-paxton


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