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MROnics used in MR Linac applications

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  • Full or part time
    Prof F Van den Heuvel
    Dr Sam Vinko
  • Application Deadline
    No more applications being accepted

Project Description

HE PROJECT
The advent of clinically implemented MR Linacs generates an excess of available imaging data. This can be leveraged to predict the outcome of the treatment and provide valuable information in a biological adaptation of a patients’ treatment.

In this project we will use the latest Artificial intelligence and machine learning tools combined with a more classical model based technique to find imaging markers, singular or rate based which can be predictors.

1) Increase potential biomarker candidates by including information from MR imaging obtained during treatment;

2) Develop a strategy to combine biomarkers which enables the inclusion of quantitative and semi--quantitative data (e.g. patient condition, general assessment);

3) Increase the data set used to investigate the mechanisms of radiation--induced tissue damage and the evolution of oxygenation, and

finally,

4) Create a clinical data set which can inform a Generative Adversary network (GAN) which can, in turn, be used to train neural networks that have been built with less detailed information.

It is clear that a suitable candidate is well versed in clinical medical physics but also would need to have a good underpinning in machine learning techniques and modern computer languages (Python, Julia, TensorFlow).

THE TRAINING
Our group combines basic physics, computer science and clinical medical physics and could later lead to opportunities in either clinical or medical environments.

PUBLICATIONS
Teoh, F. Fiorini, B. George, K. A. Vallis, and Van den Heuvel, F. Proton vs photon: A model-based approach to patient selection for reduction of cardiac toxicity in locally advanced lung cancer.Radiotherapy and Oncology , 2019/08/19 In Press.

Van den Heuvel Frank , George Ben, Schreuder Niek, and Fiorini Francesca. Using stable distributions to characterize proton pencil beams. Medical Physics, 45(5):2278–2288, 2018.

Francesca Fiorini, Niek Schreuder, and Van den Heuvel, Frank . Technical note: Defining cyclotron based clinical scanning proton machines in a FLUKA monte carlo system. Medical Physics , 45(2):963–970, 2018.

Funding Notes

All complete applications received by 12 noon (UK time) on Friday 10 January 2020 will automatically be considered for all relevant competitive University and funding opportunities, including the Clarendon Fund, Medical Research Council funding, and various College funds. Please refer to the Funding and Costs webpage (https://www.ox.ac.uk/admissions/graduate/courses/dphil-oncology) for this course for further details relating to funded scholarships and divisional funding opportunities.

Funded studentships are highly competitive and are awarded to the highest ranked applicant(s) based on the advertised entry requirements for each programme of study.

References

Whilst you must register three referees, the department may start the assessment of your application if two of the three references are submitted by the course deadline and your application is otherwise complete. Please note that you may still be required to ensure your third referee supplies a reference for consideration.

Academic references are strongly encouraged, though you may use up to one professional reference provided that it is relevant to the course.

How good is research at University of Oxford in Clinical Medicine?

FTE Category A staff submitted: 238.51

Research output data provided by the Research Excellence Framework (REF)

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