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The Rousseau lab is interested in decoding how protein degradation by the proteasome is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. The proteasome recognises, unfolds, and degrades faulty proteins that have been tagged with ubiquitin to maintain the integrity of the proteome. Defects in the proteasome give rise to various human diseases, such as cancer and neurodegenerative disorders. We recently reported that proteasome assembly and activity is increased upon various stresses. This involves the transport of proteasome assembly chaperone (PAC) mRNAs along actin structures and their relocalisation to a specific subcellular localisation upon stress to stimulate their translation.
The goal of this project is to define how actin remodelling controls PAC mRNA translation and cell survival using budding yeast. The project will offer training opportunities in state-of-the-art technologies such as live-cell mRNA tracking using confocal microscopy, mRNA pull-down followed by proteomics and CRISPR/Cas9 genome editing.
Please see our website for further details on the programme:
Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee
Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.
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https://www.dundee.ac.uk/study/pgr/research-areas/life-sciences/
To find Life Science MSc by Research you should select the following options:
· Course type: Research Postgraduate
· Keyword: Life
When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.
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