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MSc by Research: How are SUMO substrates selected for modification ?

   School of Life Sciences

  Prof R Hay  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Extensive proteomic analysis has documented the co-ordinate SUMO modification of many components of large nucleoprotein complexes. An emerging mode of action of SUMO is that multiple members of large protein complexes, rather than single proteins, are targeted for modification by the limited number of SUMO E3 ligases. Although the modification of components of the complexes may be sub-stoichiometric this still allows them to interact non-covalently with the more abundant SIM sequences. This serves to increase the stability of the complex such that it attains or retains biological activity. In this situation SUMO modification is acting as a relatively unspecific biological glue. The aim of the project is to determine the molecular basis for the recognition of the nucleoprotein complexes and the SUMO modification of their protein components. 

Please see our website for further details on the programme:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.

To find Life Science MSc by Research you should select the following options:

·      Course type: Research Postgraduate

·      Keyword: Life

When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application that we have the following deadline dates throughout the year:

September Starts - Application Deadline 1st May, Interview Date - Late June

January Starts - Application Deadline 1st Sep, Interview Date - Late October

May Starts - Application Deadline 1st Feb, Interview Date Late March

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