We recently identified a plant homologue of the mammalian membrane bound O-acyl transferase family that includes Hedgehog acyl-transferase (Hhat), GOAT and Porcupine. These enzymes add fatty acids to Hedgehog, Ghrelin and Wnt peptides/proteins respectively to control their activity in regulating many aspects of mammalian biology from cell division to hunger responses. Based on the existence of a plant Hhat/GOAT/Porcupine homologue we have hypothesised the existence of a fatty acid modified plant peptide homologue of hedgehog, named Veghog. This project aims to physiologically, developmentally and molecularly characterise loss-of-function mutants in the putative Vegehog acyl-transferase (VAT) to understand the role of VAT/Veghog in plant growth and development. We also aim to use cutting edge chemical biology tools to identify Veghog itself.
This project will provide training in plant physiology, protein biochemistry/molecular biology, chemical biology, proteomics, methods development and quantitative analysis. Potential applicants are encouraged to contact Piers Hemsley (firstname.lastname@example.org) for further information and informal discussion about the project.
Please see our website for further details on the programme:
Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee
Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.
You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.
To find Life Science MSc by Research you should select the following options:
· Course type: Research Postgraduate
· Keyword: Life
When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.
Please note when submitting an application that we have the following deadline dates throughout the year:
September Starts - Application Deadline 1st May, Interview Date - Late June
January Starts - Application Deadline 1st Sep, Interview Date - Late October
May Starts - Application Deadline 1st Feb, Interview Date Late March