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  MSc by Research: Identification of PP2A substrates during oocyte meiosis

   School of Life Sciences

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  Dr Federico Pelisch  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Female meiosis is particularly error-prone, leading to chromosomally abnormal embryos that account for >10% of human pregnancies and, for women nearing menopause, the incidence may exceed 50%. Therefore, understanding the molecular events that guarantee proper chromosome segregation during female meiosis is of paramount relevance. In spite of this, and in contrast to mitosis, we still do not have a molecular understanding of the events regulating meiotic chromosome segregation. Our recent work has focused on chromosome segregation during oocyte meiosis using the nematode C. elegans as a model organism, which provides an excellent system for studying meiosis. We are interested in the signalling networks that guarantee that every single protein performing a function during meiosis is present at the right place, in the right time. In many instances these signals are in the form of post-translational protein modifications (PTMs) and we focus on two of these: phosphorylation and sumoylation. We recently uncovered a role for the protein phosphatase PP2A:B56 in chromosome alignment during meiosis (Bel Borja et al 2000, eLife).   

In order to understand the mechanism involved in PP2A-mediated chromosome alignment, this project aims at identifying meiotic PP2A:B56 substrates and their role during meiosis. We will employ state-of-the-art mass spectrometry to identify phosphorylation events in vivo during meiosis. Once identified, we will study the roles that these sites play during meiosis in vivo though time-lapse microscopy, with high spatial and temporal resolution, and biochemical methods. 

Please see our website for further details on the programme:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.

To find Life Science MSc by Research you should select the following options:

·  Course type: Research Postgraduate

·  Keyword: Life

When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application that we have the following deadline dates throughout the year:

September Starts - Application Deadline 1st May, Interview Date - Late June

January Starts - Application Deadline 1st Sep, Interview Date - Late October

May Starts - Application Deadline 1st Feb, Interview Date - Late March 

Biological Sciences (4)

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 About the Project