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MSc by Research: Investigating novel Cryptosporidium oocyst wall proteins


   School of Life Sciences

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Cryptosporidium is a waterborne pathogen, which causes a deadly diarrheal disease, that is transmitted as an oocyst in the environment. The oocyst wall is critical for effective transmission because it acts as a hardy shell and protects the infective pathogen from harsh environmental conditions and nearly all disinfectants – including chlorination. There are currently no vaccines for cryptosporidiosis and the only approved drug is ineffective in populations that need it most, immunocompromised patients and infants.  

To better understand transmission of Cryptosporidium, our lab has generated an in depth list of the proteins that comprise the oocyst wall. Many of these proteins are uncharacterized and have unknown functions. This project will have an important role in characterizing the novel proteins for the first time by developing transgenic parasite strains via molecular cloning and CRISPR/Cas9. Transgenic lines will be further studied by in vitro cell culture and fluorescent microscopy to understand the protein localization within the parasite.  

Prominent techniques:  

CRISPR/Cas9  

Gibson cloning  

In vitro cell culture 

Fluorescent microscopy  

Please see our website for further details on the programme:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.

https://www.dundee.ac.uk/study/pgr/research-areas/life-sciences/

To find Life Science MSc by Research you should select the following options:

·   Course type: Research Postgraduate

·   Keyword: Life

When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application that we have the following deadline dates throughout the year:

September Starts - Application Deadline 1st May, Interview Date - Late June

January Starts - Application Deadline 1st Sep, Interview Date - Late October

May Starts - Application Deadline 1st Feb, Interview Date Late March


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