New antibiotics are needed to treat antibiotic resistant pathogens such as P. aeruginosa which is a major driver of morbidity and mortality in cystic fibrosis and bronchiectasis. Iron is essential for growth of P. aeruginosa and several commercially available iron chelators are available as potential treatments for chronic P. aeruginosa infection. The host response through mediators such as LCN2 aims to deplete iron at inflammatory sites. We therefore hypothesized that P. aeruginosa adapts to iron deplete conditions in chronic infections. The student will examine whole genome sequence data from P. aeruginosa isolates to examine mutations in genes for iron metabolism. Iron will be measured in matched sputum samples from these patients, with microscopy methods used to identify update of iron by macrophages in-vivo. Experimental evolution experiments will be conducted through growth of P. aeruginosa in iron deplete conditions followed by sequencing of evolved strains. The aim of the study is to identify how P. aeruginosa adapts to iron depletion, to identify targets to restore P. aeruginosa requirement for iron and therefore develop a novel antibiotic strategy.
Type: microbiology, translational, wet lab/dry lab Disease areas: Bronchiectasis, cystic fibrosis, antibiotic resistance
Fully funded scholarships are available to a limited number of students. These scholarships are funded for 1 year.
- tuition fees (UK rate only)
- stipend –2022-23 - £16,062
- research consumables
We can only fund Home Fees. International students are welcome to apply but, if successful, must be able to fund the difference in fees.
Must possess or be expected to possess by the time of starting the Masters by Research, at least one of the following:
- First class, or 2(i) honours degree in a relevant scientific discipline, or equivalent
English language requirements
IELTS minimum overall score of 6.5 (Reading 5.5, Listening 5.5, Speaking 5.5 Writing 6.0)
How to apply
Candidates should provide a CV and a short statement (up to 500-words) supporting their application and email it to [Email Address Removed] by 30th November 2022. The short statement should include details of:
- Their personal motivation to undertake a multidisciplinary Masters by Research in respiratory medicine and infectious diseases.
- Why this training programme is of interest to them.
- Their preferred project and why they selected a particular project
Informal Dundee should be sent to the course director Professor James Chalmers: [Email Address Removed]
Candidates are strongly encouraged to discuss their applications with us in advance, and we are happy to arrange discussions with our previous postgraduate students.
Masters of research training programme in Respiratory Medicine and Infectious Disease
The COVID-19 pandemic illustrates the critical importance of infectious diseases and respiratory medicine to global public health. Along with acute respiratory infections such as COVID-19 and pneumonia, non-communicable diseases such as COPD, asthma and bronchiectasis affects millions of people worldwide, with few effective or proven treatments. Research into respiratory infection is unlocking the potential of the microbiome to discover new treatments and diagnostic tests, with the potential to support precision medicine. Understanding the immunology of respiratory infections can lead to new treatments and vaccines to prevent avoidable morbidity and mortality. A masters in research in this exciting field will lay the perfect foundation for a career in medical research.
This course is particularly well suited to candidates who may wish to pursue a PhD degree in future.
This masters training programme offers opportunities for up to 3 students per year to join our research community.
Based in the Division of Molecular and Clinical Medicine at Ninewells Hospital in Dundee but with collaborators in multiple institutions, students will be embedded in multidisciplinary research teams conducting cutting edge research. Students will work alongside both clinicians and scientists conducting bench to bedside translational research. Excellent research training opportunities are provided, and previous masters and PhD students have won national and international awards as well as publishing high impact papers arising from their studies. Training opportunities include those provided by the Doctoral Academy in Dundee.