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The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. If you have your own ideas for a research project in this area, we would love to hear from you! Please reach out to one of the project supervisors above to discuss your ideas.
You can find further information about our academic requirements and programme structure here.
Introduction: Lipodystrophy, a rare disorder characterised by abnormal or deficient adipose tissue formation and distribution, presents a significant challenge to affected individuals. It leads to severe metabolic complications such as diabetes and fatty liver disease, substantially impacting the quality of life and, in some cases, becoming life-threatening. Unfortunately, treatment options for these conditions remain limited.
Research Background: Recent pre-clinical studies conducted in our laboratory have yielded promising therapeutic opportunities. We have successfully labelled adipose-derived stem cells (ASCs) with green fluorescent protein (GFP) in mice, using adeno-associated virus (AAV) vectors. This opens the possibility to explore autologous cell therapy as a means to restore adipose functionality and potentially treat lipodystrophic disorders. However, before this can become a viable treatment option, further foundational research is essential.
Project Objectives: This proposal seeks to establish a robust protocol for the isolation and sorting of ASCs. These cells play a pivotal role in adipose tissue biology, and a comprehensive understanding of their properties is crucial for various research and therapeutic applications. Specifically, the project aims to:
Significance: This project aims to significantly advance our understanding of ASCs and their potential applications in regenerative medicine for lipodystrophy disorders. Refining the isolation and sorting protocol for GFP-labelled ASCs will bring us closer to a realistic therapeutic strategy for those suffering from lipodystrophy. This research will continue to offer hope for improved patient outcomes and an enhanced quality of life. In conclusion, this project represents a unique opportunity to contribute to cutting-edge research in the field of regenerative medicine and address an urgent medical need.
Methods/skills to be used:
Cell isolation, flow cytometry, immunofluorescent imaging, and cell culture.
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Applicants to this project should hold a minimum of a 2:1 UK Honours degree (or international equivalent) in a relevant subject.
We encourage applications from all backgrounds and communities, and are committed to having a diverse, inclusive team.
Informal enquiries are encouraged, please contact Dr George McIlroy ([Email Address Removed]) for further information.
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APPLICATION PROCEDURE:
Please note: This is a self-funded opportunity.
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