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  MSc By Research: Isolation and Sorting of Adipose-Derived Stem Cells for Cell Therapy Applications in Lipodystrophy Disorders


   School of Medicine, Medical Sciences & Nutrition

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  Dr George McIlroy, Dr Andrea Holme  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. If you have your own ideas for a research project in this area, we would love to hear from you! Please reach out to one of the project supervisors above to discuss your ideas.

You can find further information about our academic requirements and programme structure here.

Introduction: Lipodystrophy, a rare disorder characterised by abnormal or deficient adipose tissue formation and distribution, presents a significant challenge to affected individuals. It leads to severe metabolic complications such as diabetes and fatty liver disease, substantially impacting the quality of life and, in some cases, becoming life-threatening. Unfortunately, treatment options for these conditions remain limited.

Research Background: Recent pre-clinical studies conducted in our laboratory have yielded promising therapeutic opportunities. We have successfully labelled adipose-derived stem cells (ASCs) with green fluorescent protein (GFP) in mice, using adeno-associated virus (AAV) vectors. This opens the possibility to explore autologous cell therapy as a means to restore adipose functionality and potentially treat lipodystrophic disorders. However, before this can become a viable treatment option, further foundational research is essential.

Project Objectives: This proposal seeks to establish a robust protocol for the isolation and sorting of ASCs. These cells play a pivotal role in adipose tissue biology, and a comprehensive understanding of their properties is crucial for various research and therapeutic applications. Specifically, the project aims to:

  • Optimise the isolation method and assess viability of isolated ASCs.
  • Evaluate efficiency of sorting GFP-labelled ASCs and investigate their functional characteristics.

Significance: This project aims to significantly advance our understanding of ASCs and their potential applications in regenerative medicine for lipodystrophy disorders. Refining the isolation and sorting protocol for GFP-labelled ASCs will bring us closer to a realistic therapeutic strategy for those suffering from lipodystrophy. This research will continue to offer hope for improved patient outcomes and an enhanced quality of life. In conclusion, this project represents a unique opportunity to contribute to cutting-edge research in the field of regenerative medicine and address an urgent medical need.

 Methods/skills to be used:

Cell isolation, flow cytometry, immunofluorescent imaging, and cell culture.

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Applicants to this project should hold a minimum of a 2:1 UK Honours degree (or international equivalent) in a relevant subject.

We encourage applications from all backgrounds and communities, and are committed to having a diverse, inclusive team.

Informal enquiries are encouraged, please contact Dr George McIlroy ([Email Address Removed]) for further information.

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APPLICATION PROCEDURE:

Please note: This is a self-funded opportunity.

  • Prospective students should contact the lead supervisor (via the email address listed above) to discuss the research project and complete a proposal form prior to / or shortly after applying.
  • Formal applications can be completed online: https://www.abdn.ac.uk/pgap/login.php
  • You should apply for Medical Sciences (MSc) to ensure your application is passed to the correct team.
  • Please clearly note the name of the supervisor and the project title on the application form. If this is not included, your application may not be considered for the project.
  • Candidates should have (or expect to achieve) a minimum of a 2:1 UK Honours degree (or international equivalent) at undergraduate level.
  • Your application must include: a personal statement, an up-to-date copy of your academic CV, and clear copies of your educational certificates and transcripts.
  • If you are still undertaking your undergraduate degree, it is helpful to the selection panel if you could provide documentation showing your grades to date (this can be a screenshot from an online portal).
  • Please note: Project supervisors will not respond to requests for funding assistance.
  • If you require any additional assistance in submitting your application or have any queries about the application process, please don't hesitate to contact us at [Email Address Removed]
Biological Sciences (4) Medicine (26)

Funding Notes

This is a self-funding project open to students worldwide. Our typical start dates for this programme are February or October.
Fees for this programme are £4,712 for home/UK students, and £24,860 for international students.
Additional research costs / Bench fees of £3,000 will also apply.
The Scottish Government offers postgraduate loans to those due to start a Masters (taught or research) programme.

References

1. https://onlinelibrary.wiley.com/doi/10.1111/dme.15214
2. https://www.sciencedirect.com/science/article/pii/S2329050122001395?via%3Dihub
3. https://www.sciencedirect.com/science/article/pii/S009286740801194X?via%3Dihub

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