Posttranslational modifications of proteins are important regulatory events that impact most if not all physiological functions of cells. The lab is interested in how different cell fates are established by stem cells that can divide asymmetrically. This is important to understand as deregulated fate decisions by stem cells are suspected to lead to tumour-like growth.
This project will focus on phosphorylation of proteins in a model system stem cell, the neural stem cells of the fruit fly. You will use state-of-the-art live cell imaging of CrispR generated fluorescent reporters of kinase activity as well as nanobody based reporters to detect specifically the phosphorylated pool of candidate proteins in cells to study their dynamics and manipulated their localization. This project will shed light on our understanding of how the evolutionarily conserved PAR polarity complex drives cell fate decisions.
Please see our website for further details on the programme:
Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee
Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.
You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.
To find Life Science MSc by Research you should select the following options:
· Course type: Research Postgraduate
· Keyword: Life
When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.
Please note when submitting an application that we have the following deadline dates throughout the year:
September Starts - Application Deadline 1st May, Interview Date - Late June
January Starts - Application Deadline 1st Sep, Interview Date - Late October
May Starts - Application Deadline 1st Feb, Interview Date Late March