This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience. You will have the opportunity to select a research project from a variety of thematic areas of research.
You will be part of our collaborative working environment and have access to outstanding shared facilities such as microscopy and proteomics. Throughout your year, you will develop an advanced level of knowledge on your topic of interest as well as the ability to perform independent research in the topic area. Alongside basic science training in experimental design, data handling and research ethics, we will help you to develop skills in critical assessment and communication. This will be supported by workshops in scientific writing, presentation skills, ethics, laboratory safety, statistics, public engagement and optional applied bioinformatics.
Many drugs that are developed experimentally against pathogens fail, and one of the most common causes is due to an inability to efficiently enter the cell. This can be a result of acquisition of resistance (AMR) or of an intrinsic inability to cross the plasma membrane. This project will investigate the use of camelid nano-bodies (mini-immunoglobulins) as a means to provide access to the cell interior in the African trypanosome. We have developed a panel of nano-bodies which bind to surface proteins of the trypanosomes, and which we believe will be internalised. Uptake of these nano-bodies coupled to novel drug compounds has the potential to provide a new approach to drug therapy against trypanosomes and related parasites.
The project will involve high resolution imaging, protein chemistry and drug design and will provide an excellent training in the burgeoning area of immunotherapeutics. Interested candidates can contact Prof Field at [email protected]