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MSc by Research Programme: Development of tools suited for the in vivo identification and study of protein Complexes in Phytophthora capsici, required for infection.


School of Life Sciences

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Dr E Huitema No more applications being accepted Self-Funded PhD Students Only

About the Project

This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience. You will have the opportunity to select a research project from a variety of thematic areas of research.

You will be part of our collaborative working environment and have access to outstanding shared facilities such as microscopy and proteomics. Throughout your year, you will develop an advanced level of knowledge on your topic of interest as well as the ability to perform independent research in the topic area. Alongside basic science training in experimental design, data handling and research ethics, we will help you to develop skills in critical assessment and communication. This will be supported by workshops in scientific writing, presentation skills, ethics, laboratory safety, statistics, public engagement and optional applied bioinformatics.

The period of study is one year full-time or two years part-time research, which includes two months to write up the thesis. Please apply via the UCAS postgraduate application form: https://digital.ucas.com/courses/details?coursePrimaryId=c735d826-42b6-ca1f-50db-2a3ac6f68718

Broad host range pathogens, such as the oomycete pathogen Phytophthora capsici , can cause significant disease on a wide range of plants. We have uncovered exciting new evidence demonstrating that P. capsici regulates the expression of its gene complement by sensing its host environment. In order to study the role of P. capsici proteins in dynamic host sensing however, there is a great need for tools that allow the study of both the transcriptional processes and the functional complexes underpinning their regulation, in this pathogen. In this project, we will pursue the following aims:

1. Devise an in vivo protein labelling technique, suited for the identification of
functional protein complexes during infection
2. Identify partners of candidate transcriptional regulators, important for virulence
3. Validate and characterise protein complexes, required for infection of plants.

During this project, the researcher will be trained in microbiology, protein chemistry, molecular biology as well as proteomics. Particular attention will be paid to the professional development of researchers on this project by providing career support and active mentoring.


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