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MSc by Research Programme: Proteins in the biofilm matrix of Bacillus subtilis

About This PhD Project

Project Description

This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience. You will have the opportunity to select a research project from a variety of thematic areas of research.

You will be part of our collaborative working environment and have access to outstanding shared facilities such as microscopy and proteomics. Throughout your year, you will develop an advanced level of knowledge on your topic of interest as well as the ability to perform independent research in the topic area. Alongside basic science training in experimental design, data handling and research ethics, we will help you to develop skills in critical assessment and communication. This will be supported by workshops in scientific writing, presentation skills, ethics, laboratory safety, statistics, public engagement and optional applied bioinformatics.

The period of study is one year full-time or two years part-time research, which includes two months to write up the thesis. Please apply via the UCAS postgraduate application form: https://digital.ucas.com/courses/details?coursePrimaryId=c735d826-42b6-ca1f-50db-2a3ac6f68718

Biofilm formation is the process by which single celled microbes form an adherent community. Bacillussubtilisis a Gram-positive bacterium that lives in the soil and can form biofilms on the roots of plants. The cells produce an extracellular matrix that surrounds and protects the cells in the biofilm. We want to further our understanding of how the proteins in the biofilm matrix assemble into higher order forms (these can be fibres and films) and to understand how they let the three dimensional structure of the mature biofilm develop. The student undertaking the project would be exposed to molecular biology techniques in combination with biochemistry and some biophysical analysis methods.

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