About the Project
You will be part of our collaborative working environment and have access to outstanding shared facilities such as microscopy and proteomics. Throughout your year, you will develop an advanced level of knowledge on your topic of interest as well as the ability to perform independent research in the topic area. Alongside basic science training in experimental design, data handling and research ethics, we will help you to develop skills in critical assessment and communication. This will be supported by workshops in scientific writing, presentation skills, ethics, laboratory safety, statistics, public engagement and optional applied bioinformatics.
The period of study is one year full-time or two years part-time research, which includes two months to write up the thesis. Please apply via the UCAS postgraduate application form: https://digital.ucas.com/courses/details?coursePrimaryId=c735d826-42b6-ca1f-50db-2a3ac6f68718
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. We aim to understand the role of protein complexes including the exocyst. This project seeks to answer mechanistic questions regarding 1) the regulation of protein structural mechanics in polarized trafficking, 2) and the consequences of signalling on this pathway and its organization. Because signalling in polarized trafficking is affected in metastasis of cancer, we position our research for the broadest impact in forming a foundation for drug discovery. We take a reconstitution and synthetic biology approach in combination with the powerful tools available for microscopy. Our philosophy is to address these questions of challenging biology using quantitative methods in a hypothesis-driven approach.
We are excited to introduce this interdisciplinary research to a highly motivated and ambitious student, who will be expected to have exemplary communication skills and an ability to collaborate. The student will emerge a master in state-of-the-art protein approaches. For any questions on the nature of the proposed research, please to not hesitate to contact me directly [Email Address Removed] or by visiting our website. https://sites.dundee.ac.uk/david-murray-lab/
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