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MSc by Research Programme: Signalling pathways controlling protein degradation upon stress


About This PhD Project

Project Description

This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience. You will have the opportunity to select a research project from a variety of thematic areas of research.

You will be part of our collaborative working environment and have access to outstanding shared facilities such as microscopy and proteomics. Throughout your year, you will develop an advanced level of knowledge on your topic of interest as well as the ability to perform independent research in the topic area. Alongside basic science training in experimental design, data handling and research ethics, we will help you to develop skills in critical assessment and communication. This will be supported by workshops in scientific writing, presentation skills, ethics, laboratory safety, statistics, public engagement and optional applied bioinformatics.

The period of study is one year full-time or two years part-time research, which includes two months to write up the thesis. Please apply via the UCAS postgraduate application form: https://digital.ucas.com/courses/details?coursePrimaryId=c735d826-42b6-ca1f-50db-2a3ac6f68718

Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders. Our interest is to understand how the activity of the ubiquitin-proteasome system is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. We recently reported that proteasomal degradation is regulated upon proteotoxic stresses in a phosphorylation-dependent manner (Rousseau and Bertolotti, 2016). The new project will focus on how protein phosphorylation events regulate protein homeostasis and cell survival. An additional project consists in developing new tools to characterize how proteasome homeostasis is regulated in cells, and to use these tools to identify new regulators and drugs modulating proteasomal degradation. Both yeast and mammalian systems will be used for this project.

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