MSc by Research: Protein secretion landscapes in human immune cells

Roughly one third of the human genome encodes secretory and membrane proteins. Following synthesis in the endoplasmic reticulum (ER), these proteins are captured into transport vesicles for delivery within the cell. ER export receptors play critical roles in deciding which proteins get trafficked, yet we know relatively little about the mechanisms by which these recognition events occur. 

This project aims to examine the full spectrum of secretory proteins that use different export receptors in different immune cells. By making genetically modified T- and B-cells, we aim to differentiate cells into different effector cell types and use proteomics to understand (i) the full spectrum of proteins secreted by different specialized cells; (ii) the impact of knock-out or knock-down of specific secretion machineries on the secretome landscape; and (iii) the mechanisms that different export receptors use to engage diverse cargo clients.  

The project will allow a student to develop skills in a variety of biochemical and cell biological approaches, including genome editing, cell culture, proteomics, biochemistry and live-cell imaging. Both the Miller and Howden labs are small groups, focused on questions central to this project, and provides a supportive mentoring environment. 

Please see our website for further details on the programme:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.

https://www.dundee.ac.uk/study/pgr/research-areas/life-sciences/

To find Life Science MSc by Research you should select the following options:

· Course type: Research Postgraduate

· Keyword: Life

When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website