MSc by Research: Resolving immune cell proteomes to subcellular resolution

Immune activation triggers dramatic proteome remodelling. Using high sensitivity mass spectrometry we have mapped immune cell proteomes, providing novel insights into immune cell phenotypes and revealing the metabolic and protein synthesis machinery and environmental sensors that shape cell fate. However, our analysis has provided little insight into the subcellular dynamics of the immune cell proteome. The location of proteins to specific cellular compartments, and their movement between compartments, is essential for core cellular activities. Indeed, mis-localisation of proteins within the cell is linked to a range of diseases.

This project aims to develop novel tools to explore the subcellular proteome of lymphocytes. These tools will be valuable for understanding how protein localisation is impacted by immune activation or by the modulation of key signalling pathways. The project will provide the opportunity to master cutting edge skills in protein biochemistry and mass spectrometry and will generate new mechanistic insights into the activity of immune cells.  

Please see our website for further details on the programme:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.

https://www.dundee.ac.uk/study/pgr/research-areas/life-sciences/

To find Life Science MSc by Research you should select the following options:

· Course type: Research Postgraduate

· Keyword: Life

When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website.