The epigenetic mark of DNA methylation is established by DNMT (DNA methyltransferase) enzymes and has been shown to correlate with transcriptional states and influence cell identity and tumorigenesis in mammalian cells. The recent discovery that TET (Ten-Eleven-Translocation) enzymes produce 5-hydromethylcytosine (5hmC), 5- formylcytosine (5fC), 5-carboxycytosine (5caC) and mediate passive and active DNA demethylation in the genome has opened a new avenue to understand how DNA methylation dynamics affect transcriptional programs (Rasmussen and Helin, 2016). Mutations in TET2 and DNMT3A are frequently found (~10-50% of patients) in a wide range of blood diseases, including Acute Myeloid Leukemia (AML) and Myelodysplastic syndrome (MDS). However, the downstream events that cause hematopoietic stem cell to expand and transform following the occurrence of these mutations are currently unknown.
The 1-year Master Project will be aligned with on-going projects in the lab to characterize the effect of aberrant DNA methylation on gene expression and link this to haematological diseases. Students with an interest in epigenetics and gene regulation are most welcome to contact Kasper on [Email Address Removed] and visit the lab for an informal talk about detailed projects.
Please see our website for further details on the programme:
Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee
Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.
You apply for this course using our Direct Application System. Once you've signed up for an account you'll be asked to search for a course.
To find Life Science MSc by Research you should select the following options:
· Course type: Research Postgraduate
· Keyword: Life
When you complete your form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.
Please note when submitting an application that we have the following deadline dates throughout the year:
September Starts - Application Deadline 1st May, Interview Date - Late June
January Starts - Application Deadline 1st Sep, Interview Date - Late October
May Starts - Application Deadline 1st Feb, Interview Date Late March