Chronic lung infections are associated with poor quality of life and mortality for people with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The process of chronic colonisation allows pathogens to evolve and adapt over time to cope with changing selection pressures, co-infecting species and antimicrobial therapies. The mechanisms behind this bacterial evolution are poorly understood. The aim of this project is to elucidate the adaptive mechanisms involved in chronic colonisation. If we can target the key genes involved (or their products) early in the acute infection phase, we could prevent the development of a chronic infections and consequent eradication challenges. The project will involve a range of techniques including microbiology, cloning, protein purification, molecular techniques, cell biology, protein:protein interactions.
This is a funded M.Sc. project. The successful candidate will receive full EU fees and a stipend of €16, 000 per annum over 20 months.