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  MScR: Designing mechanism-based cancer therapies


   School of Cellular and Molecular Medicine

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  Dr Siang-Boon Koh  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Tumours deploy a multitude of molecular stratagems to evade the effects of drugs. In particular, oncogenic factors such as RAS are frequently amplified or mutated in cancer cells. Deregulation of these major signalling pathways confers pro-tumour properties that lead to disease progression or relapse.

We recently discovered that the expression of certain RAS regulators in cancer cells can induce drug resistance. Notably, this feature is pharmacologically reversible, highlighting the prospect of cancer-specific treatment strategies that may spare normal cells.

This MScR project will investigate the fundamental mechanisms of RAS regulators in the context of therapeutic implications. The goal is to gain details that can help design more selective and effective cancer therapies. Key laboratory techniques may include drug assays, omics profiling, and imaging. The student will have the opportunity to take an integrative research approach by combining data analyses from in silico, in vitro and in vivo experimental models, as well as collaborate with other biomedical scientists.

We encourage applications from motivated and industrious individuals who are capable of thinking and working independently in the laboratory.

MSc by Research (MScR) is a 1-year research degree that provides an intensive lab-based training and a preparation for PhD study. You will carry out your studies as part of your research group – like a PhD student does. Towards the end of the year, you write up a thesis on your research and are examined on this. This degree suits students wanting to gain maximum research experience in preparation for PhD applications. 

We are keen to recruit a diverse range of students and to ensure our research is open to all. We particularly welcome applications from groups traditionally under-represented in life sciences research. Please check the University webpages for the current tuition fee information. Most MScR projects also require a bench fee. This varies depending on the research and your project supervisor can tell you the bench fee for the project.

How to apply:

Use the following link to apply: Start your application | Study at Bristol | University of Bristol

You should select the programme: Cellular and Molecular Medicine (MSc by Research)

Please ensure you upload all supporting documents as per the admissions statement (which applies to both PhD and MScR programmes): PhD Cellular and Molecular Medicine | Study at Bristol | University of Bristol

Clearly indicate the supervisor name and project title in the relevant section of the application form. The system will not allow you to submit your application without uploading a document to the research statement section.  Where this is an optional requirement, please upload a blank Word document which is headed “No research statement required”.

Applications are accepted all year round. However, the preferred entry points for study are September / January / April / July.


Biological Sciences (4)

Funding Notes

This project is available to UK or international students who wish to self-fund their MScR or who have access to their own funding.
Please contact Dr Siang-Boon directly for information about the project and how to apply ([Email Address Removed]).

Where will I study?

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