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Multi-omic analysis of single cells in cancer (MACAULAYE19CRUK)

Project Description

The ability to sequence the DNA and RNA of single cells has immense potential to revolutionise our understanding of the evolutionary processes in cancer. Integrating multiple datasets from the same cell - so called "multi-omics" - enables causative links to be made between genomic, epigenomic and transcriptomic variation that may underly functional cellular heterogeneity within a tumour.
This studentship is in the lab of Dr. Iain Macaulay, who focusses on the development of multi--omic tools for single cell analysis (see Macaulay et al. Nature Protocols 2016, Nature Methods 2015, Macaulay et al. Trends in Genetics 2017 for more information) and is part of a CRUK funded Accelerator Award led by Prof. Giovanni Tonon (Functional Genomics of Cancer Unit, Ospedale San Raffaele (OSR), Milan) and in collaboration with researchers at the Institute for Cancer Research (ICR, Suttton) which aims to deliver tools that will bring single-cell multi-omic analysis towards clinical applications.

The successful applicant with develop novel approaches for low-cost, high-throughput genomic, epigenomic and transcriptomic analysis of single cells. Taking advantage of the excellent genomics laboratory facilities at EI - including a suite of next generation sequencing platforms, automated liquid handling robots and cell sorting (FACS), and a collaborative international project environment with world leading cancer biologists in OSR and ICR, the project offers an exciting opportunity to deliver cutting-edge genomics tools that will be directly applied in cancer biology.

The successful applicant will have a strong academic background with a II-I or I degree in molecular biology, genetics or a related subject. Evidence of previous lab work experience would be desirable.

For further information and to apply, please visit our website:

Funding Notes

This project is awarded with a 4-year Cancer Research UK PhD studentship. Tuition fees are covered for UK/EU rate only (£4,327.00 2019/0 rate). Students liable for international tuition fees will need to fund the difference between the UK/EU fee level and the international fee level (£18,700. 2019/0 rate). A stipend will be provided for each year of the studentship (2019/0 rate is £19,000.00). Research training support funding is available.

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