About the Project
The supervisory team:
• Roy Goodacre – https://www.liverpool.ac.uk/integrative-biology/staff/roy-goodacre/
• Neil Perkins – https://www.ncl.ac.uk/medical-sciences/people/profile/neilperkins.html
• Claire Eyers – https://www.liverpool.ac.uk/integrative-biology/staff/claire-eyers/
• Andy Jones – https://www.liverpool.ac.uk/integrative-biology/staff/andrew-jones/
The student will receive training in several different and complementary disciplines that are needed for systems biology understanding of cellular phenotypes, which will make their future employability high. The expected outputs include: an enhanced understanding of NF-κB mediated drug resistance in cancer cells, which will lead to several publications in good journals and conference presentations, in terms of this specific application but also the development of integrative omics analyses.
Whilst predominantly based in Liverpool, the student would spend time in Newcastle throughout the PhD programme, as the model systems that will be studies are based on pioneering work from NP’s laboratories on NF-κB and cell signalling. In Liverpool the student will join a dynamic research group based in IIB where the focus is to investigate cellular metabolism and to integrate this within metabolic and transcriptional regulation.
HOW TO APPLY
CV, Letter of Application, 2 References by email to [Email Address Removed]
Informal enquiries may be made to [Email Address Removed]
The successful applicant will be expected to provide the funding for tuition fees and living expenses as well as research costs of £6,000 per year.
A fee bursary may be available for well qualified and motivated applicants.
Details of costs can be found on the University website:
Moles, A., Butterworth, J.A., Sanchez, A., Hunter, J.E., Leslie, J., Sellier, H., Tiniakos, D., Cockell, S.J., Mann, D.A., Oakley F. & Perkins, N.D. (2016) A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. Oncogene 35, 4623-32.
Hardman, G., Perkins, S., Brownridge, P.J., Clarke, C.J., Byrne, D.P., Campbell, A.E., Kalyuzhnyy, A., Myall, A., Eyers, P.A., Jones A.R. & Eyers C.E. (2019) Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation. EMBO J 38:e100847
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