About the Project
However, network reconstruction only provides limited insight into the biology of virus–host interactions, since many of these protein-protein interactions are context dependent, occur at different time and spatial scales, and differ in nature. Moreover, there is growing evidence that biological systems are hierarchically organised, but the ‘flat’ nature of network representations fails to take this property into account. New theoretical frameworks are therefore needed to account both for context variations and for the multi-scale nature of biological systems.
The aims of this project are (1) to analyse existing datasets of molecular interactions between phages and their bacterial hosts in order to reconstruct comprehensive network representations of virus–host interactions, and (2) to develop and implement a new context-specific and multi-scale modelling framework based on a concept of ‘organisation’ that renders hierarchy explicit. This project is highly interdisciplinary and suited for theory-minded candidates with a background in mathematics, computer science, physics or biology.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in mathematics, computer science, physics or biology are encouraged to apply.
Informal enquiries may be made directly to the primary supervisor.
Stoney R, Ames R, Nenadic G, Robertson DL, Schwartz JM (2015). Disentangling the multigenic and pleiotropic nature of molecular function. BMC Systems Biology 9(Suppl 6): S3.
Blasche S, Wuchty S, Rajagopala SV, Uetz P (2013). The protein interaction network of bacteriophage lambda with its host, Escherichia coli. Journal of Virology 87: 12745-12755.
Häuser R et al. (2012). Bacteriophage protein–protein interactions. Advances in Virus Research 83: 219-298.
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