About the Project
The addition of non-toxic SiQDs in encapsulation provides intrinsic orange-red photoluminescence which enables monitoring of both accumulation and degradation in vitro and in vivo. The strong red photoluminescence is stable in biological environments and is not absorbed by cells, which will provide sufficient information for monitoring the drug delivery.
The student working in this project is expected to synthesize the NP-QDs-Drug systems, investigate the uptake and toxicities after the incubation in cell culture, and study the drug targeting, triggering and releasing. The initial training on synthesis and cell culture will be provided in-house. Materials characterisation, such as SEM, TEM, XPS, XRD will be assisted by the facility platform technicians. In addition, the School/Faculty/Norwich Research Park provides an extremely stimulating scientific environment and a chance to experience interdisciplinary association of researchers and to develop communication and collaboration skills.
For more information on the supervisor for this project, please go here https://www.uea.ac.uk/chemistry/people/profile/y-chao
Type of programme: PhD
Start Date: 1st October 2021
Mode of Study: Full Time
Studentship Length: 3 year studentships have a (non-funded) 1 year ‘registration only’ period
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. Applicants should contact the primary supervisor for further information about the fee associated with the project.
Entry Requirements are Chemistry, Physics, Material Science and Engineering
The standard minimum entry requirement is 2:1
ii). Jayshree H. Ahire, Isabelle Chambrier , Anja Mueller , Yongping Bao , and Yimin Chao, ACS Applied Materials & Interfaces, 5, 7384-7391 (2013),
iii). Qi Wang, Yongping Bao, Jayshree Ahire, Yimin Chao, Advanced Healthcare Materials, 2, 459-466 (2013)
iv). Jayshree H. Ahire, Qi Wang, Paul R. Coxon, Girish Malhotra, Rik Brydson, Rongjun Chen, and Yimin Chao, ACS Applied Materials & Interfaces, 4, 3285-3292 (2012)
v). Y. Chao, A. I. Marsh, M. Behray, F. Guan, A. Engdahl, Y. Chao, Q. Wang, Y. Bao, Faraday Discussions 222, 332-349 (2020).
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