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Multimodal imaging of brain metabolism in humans in vivo


   Post-graduate Research

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  Dr Iris Asllani, Dr Alessandro Colasanti, Prof Itamar Ronen  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

The overall goal of this PhD thesis is the integration of Near Infrared Spectroscopy (NIRS)1 with arterial spin labelling (ASL) perfusion MRI2 and quantitative BOLD MRI3 for a comprehensive assessment of oxygen metabolism in the healthy brain at baseline. This is a methodology driven thesis that will provide the tools for future basic neuroscience and/or clinical applications such as mitochondria diseases and stroke. The candidate will work on proving the feasibility of multimodal imaging for providing absolute measurement of cerebral oxygen metabolism at baseline and during modulated breathing conditions, potentially including visual and/or motor activation. The PhD student will be involved in setting up and testing the NIRS system; integrating the NIRS system with the MRI scanner; concomitant acquisition of NIRS and MR images; writing software for fusion of NIRS and CBF and OEF images at the single-subject level; and image processing at the single- and group-level analyses. Successful completion of the thesis will ensure that the candidate has gained: (1) Knowledge of the fundamental principles of brain function and anatomy; Knowledge of the basic mathematical and physics of neuroimaging; (3) Ability to acquire brain images using two different hardware systems; (4) Ability to develop software for multi-modal image processing.

Keywords: fMRI, neuroscience, brain, brain metabolism, NIRS, cerebral blood flow

Applicants will need to apply via the University of Brighton portal https://evsipr.brighton.ac.uk/urd/sits.urd/run/siw_ipp_lgn.login?process=siw_ipp_app_crs


Funding Notes

Funding for the PhD student was provided to Prof. Itamar Ronen by BSMS Dean as part of his start-up package at BSMS.

References

1 Toronov V., Zhang X., Webb A.G., (2005) Near-infrared study of the underlying physiology of the functional magnetic resonance signal in humans during hypoxia, Proc SPIE Int Soc Opt Eng. 5686, 543-546.
2Borogovac A, Habeck C., Small S.A, Asllani I (2010) Mapping brain function using a 30-day interval between baseline and activation: a novel arterial spin labeling fMRI approach, Journal Cerebral Blood Flow & Metabolism, 30(10), 1721-33
3Kacmarz S., Hyder F., Preibisch C., (2020), Oxygen extraction fraction mapping with multi-parametric quantitative BOLD MRI: Reduced transverse relaxation bias using 3D-GraSE imaging, NeuroImage, 220, 117095-
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