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Multiscale and Multiphysics Optimization of an Implantable Biohybrid Lung (WS16)

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  • Full or part time
    Prof S Korossis
    Dr A Roy
    Dr L Zhao
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Loughborough University is a top-ten rated university in England for research intensity (REF2014). In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.
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Full Project Detail

This exiting and highly multidisciplinary project will develop 3D multiscale and multiphysics computational models with a view to optimizing the design, configuration, and post-operative performance of a biohybrid intracorporeal membrane oxygenator (iCMO), which can be used as a bridge to lung transplantation or destination therapy. Specifically, this project will develop a virtual testing platform for interrogating different macroscale geometries of the oxygenator and integrated blood pump units, gas-exchange hollow-fibre membrane architectures and cannulation configurations, in terms of oxygenator and pump haemodynamics and gas-species transport, ultimately aiming at developing an iCMO prototype for subsequent seeding with endothelial cells. The project will develop a clinically-relevant technology that will be readily translatable through our clinical collaborators and will dramatically benefit the quality of life of end-stage lung disease patients, by delivering an optimized biohybrid lung for ambulatory support. This project offers an excellent opportunity for developing highly interdisciplinary skills at the engineering-life sciences interface, while working in the world-leading Centre for Biological Engineering at Loughborough University, greatly enhancing the prospects for a future career in academia or the medical devices industrial sector.

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Entry requirements

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in mechanical engineering or a related subject. A relevant Master’s degree and/or experience in one or more of the following will be an advantage: computational modelling, biomedical engineering, computational modelling, biotechnology, biomedical engineering, biophysics.

Funding Notes

Please note that studentships will be awarded on a competitive basis to applicants who have applied to this project and other advertised projects starting with advert reference ‘WS’ for the School of Mechanical, Electrical and Manufacturing Engineering.
If awarded, each 3-year studentship will provide a tax-free stipend of £15,009 p/a, plus tuition fees at the UK/EU rate (currently £4,327 p/a). While we welcome applications from non-EU nationals, please be advised that it will only be possible to fund the tuition fees at the international rate and no stipend will be available. Successful candidates will be notified by 30th September 2019.

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