Multiscale and Multiphysics Optimization of an Implantable Biohybrid Lung (WS16)

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Find out more: http://www.lboro.ac.uk/study/postgraduate/supporting-you/research/

Full Project Detail
This exiting and highly multidisciplinary project will develop 3D multiscale and multiphysics computational models with a view to optimizing the design, configuration, and post-operative performance of a biohybrid intracorporeal membrane oxygenator (iCMO), which can be used as a bridge to lung transplantation or destination therapy. Specifically, this project will develop a virtual testing platform for interrogating different macroscale geometries of the oxygenator and integrated blood pump units, gas-exchange hollow-fibre membrane architectures and cannulation configurations, in terms of oxygenator and pump haemodynamics and gas-species transport, ultimately aiming at developing an iCMO prototype for subsequent seeding with endothelial cells. The project will develop a clinically-relevant technology that will be readily translatable through our clinical collaborators and will dramatically benefit the quality of life of end-stage lung disease patients, by delivering an optimized biohybrid lung for ambulatory support. This project offers an excellent opportunity for developing highly interdisciplinary skills at the engineering-life sciences interface, while working in the world-leading Centre for Biological Engineering at Loughborough University, greatly enhancing the prospects for a future career in academia or the medical devices industrial sector.

Find out more
https://www.lboro.ac.uk/departments/meme/research/research-centres/cbe/
https://www.lboro.ac.uk/departments/meme/staff/sotirios-korossis/

Entry requirements
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in mechanical engineering or a related subject. A relevant Master’s degree and/or experience in one or more of the following will be an advantage: computational modelling, biomedical engineering, computational modelling, biotechnology, biomedical engineering, biophysics.