Mybl2 in the regulation of cell fate decisions
We are interested in the molecular mechanisms regulating cell fate decisions that occur during normal development, somatic reprogramming and cancer. Using next-generation sequencing approaches such as ATAC-seq and RNA-seq we have recently found that Mybl2 regulates the first steps of somatic reprogramming, and that its overexpression leads to changes in the chromatin landscape ultimately leading to a de-regulation of key genes important for the mesenchymal-to-epithelial transition. Our follow up strategy is to determine how the cell fate decisions are regulated.
Ward, C et al. Fine-tunning MYBL2 is required for proper Mesenchymal-to-Epithelial transition during somatic reprogramming. Cell Reports 2018.
Skrypek et al. Epithelial-to-Mesenchymal transition: Epigenetic reprogramming driving cellular plasticity. Trends in Genetics 2017.