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Mybl2 in the regulation of cell fate decisions

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

We are interested in the molecular mechanisms regulating cell fate decisions that occur during normal development, somatic reprogramming and cancer. Using next-generation sequencing approaches such as ATAC-seq and RNA-seq we have recently found that Mybl2 regulates the first steps of somatic reprogramming, and that its overexpression leads to changes in the chromatin landscape ultimately leading to a de-regulation of key genes important for the mesenchymal-to-epithelial transition. Our follow up strategy is to determine how the cell fate decisions are regulated.

References

Ward, C et al. Fine-tunning MYBL2 is required for proper Mesenchymal-to-Epithelial transition during somatic reprogramming. Cell Reports 2018.
Skrypek et al. Epithelial-to-Mesenchymal transition: Epigenetic reprogramming driving cellular plasticity. Trends in Genetics 2017.

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