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Myocardial functional T1 mapping – Advanced cardiac magnetic resonance imaging techniques: improving and standardization of quantitative CMR approaches to support better healthcare


Radcliffe Department of Medicine

About the Project

Other Potential Supervisors: Konrad Werys

OCMR has an international reputation for cardiac MRI (CMR) research on all aspects from acquisition biophysics to clinical applications. The Advanced Cardiovascular Image Analysis group works together with OCMR core lab analysts and clinicians at the frontline CMR clinical facility. We address wide range of pressing practical needs of individual clinical researchers locally and large external clinical studies. Our focus is on improving and standardization of quantitative CMR approaches to support better healthcare.

We lead the CMR cardiac tissue characterisation research in the particular field called T1 mapping. The techniques pioneered in OCMR brought a wide range of publications on technical aspects and clinical application with regard to many yet unexplained relations between novel clinical and imaging biomarkers. We actively engage in big biomedical data aspects, and move the field from the current gold standard, manual and semi-automatic heart analysis, towards fully automated approaches with particular attention to the strict quality control appropriate for clinical applications. All research projects in our environment aim for immediate clinical application, expecting impacts capable of changing clinical practice.

New members joining this multidisciplinary group are usually experts in either technical or bio-medical science. We provide compatible hands on training and advice to complement specific set of skills required for their chosen research topic. Needs are assessed termly on individual basis, making use of excellent selection of courses organised internally and externally to the Oxford University.

As well as the specific training detailed above, students will have access to high-quality training in scientific and generic skills, as well as access to a wide-range of seminars and training opportunities through the many research institutes and centres based in Oxford.

The Department has a successful mentoring scheme, open to graduate students, which provides an additional possible channel for personal and professional development outside the regular supervisory framework. We hold an Athena SWAN Silver Award in recognition of our efforts to build a happy and rewarding environment where all staff and students are supported to achieve their full potential.

Funding Notes

Funding for this project is available to scientists through the RDM Scholars Programme, which offers funding to outstanding candidates from any country. Successful candidates will have all tuition and college fees paid and will receive a stipend of £18,000 per annum.

For October 2021 entry, the application deadline is 8th January 2020 at 12 noon midday, UK time.

Please visit our website for more information on how to apply.

References

S.K. Piechnik, V.M. Ferreira, E.Dall'Armellina, L.E. Cochlin, S. Neubauer, M.D.Robson. Shortened Modified Look-Locker Inversion recovery clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. Journal of Cardiovascular Magnetic Resonance 2010, 12:69

Ferreira VM, Piechnik SK, Dall'Armellina E, Karamitsos TD, Francis JM, Ntusi N, Holloway C, Choudhury RP, Kardos A, Robson MD, Friedrich MG, Neubauer S. 2014. Native T1-mapping detects the location, extent and patterns of acute myocarditis without the need for gadolinium contrast agents.J Cardiovasc Magn Reson, 16pp. 36.

Piechnik SK, Ferreira VM, Lewandowski AJ, Ntusi NA, Banerjee R, Holloway C, Hofman MB, Sado DM, Maestrini V, White SK, Lazdam M, Karamitsos T, Moon JC, Neubauer S, Leeson P, Robson MD. 2013. Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI.J Cardiovasc Magn Reson, 15pp. 13.

Piechnik SK, Neubauer S, Ferreira VM. “State-of-the-Art Review: Stress T1-mapping - Technical considerations, Pitfalls and Emerging Clinical Applications “. Magnetic Resonance Materials in Physics, Biology and Medicine, 1-11, 2017

Piechnik SK, Jerosch-Herold M. State-of-the-art review: stress T1 mapping-technical considerations, pitfalls and emerging clinical applications. The international journal of cardiovascular imaging. 28 Aug 2017


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