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Nano-engineered Delivery Systems for the Targeted Delivery of Oncology Drugs for Non-Small Cell Lung Cancer

  • Full or part time
    Dr H McCarthy
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Lung cancer is the most common cancer worldwide accounting for 11.6% of the global burden. The standard of care (SoC) chemotherapy typically involves a ‘cocktail’ of drugs which confer debilitating side-effects, resulting in sub-optimal dosing with a reduced clinical efficacy.
This PhD project is designed to modify this SoC regimen to be incorporated into the RALA++ patented technology, developed by Phion Therapeutics, for targeted efficient delivery to tumours. RALA++ can be used to deliver nucleoside and nucleotide analogue drugs specifically to solid tumours following intravenous administration in a nano-formulation. This projects forms part of an exciting collaborative partnership between Dr Buckley, a cancer researcher with expertise in personalised medicine, and Professor McCarthy from Phion Therapeutics, a pharmaceutical company dedicated to optimising therapeutic value through precise and effective drug delivery.
The student will benefit from training in both an academic and industry setting including a 6 month placement in Phion Therapeutics. The project workplan encompasses a broad range of molecular biology, physiochemical and in vivo techniques providing the student with an excellent training environment and key transferable skills for future development.

Funding Notes

Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Molecular Biology, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date

How good is research at Queen’s University Belfast in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 33.00

Research output data provided by the Research Excellence Framework (REF)

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