About the Project
These externally wearable nano-hydrogel bandages will be made of polymer or sericin with embedded plasmonic nanostructures carrying the “reporter molecules”. The ROS from the wound site, once absorbed by the hydrogel will be transported to the embedded gold or silver nanostructures where they will chemically interact with the “reporter molecules”. These custom-made reporter molecules will then undergo specific reactions with ROS to give a chemical spectral fingerprint that is detectable using optical vibrational Raman spectroscopy. A suitable specialized hand-held Raman device working on the principles of surface enhanced spatially offset Raman spectroscopy (SESORS) (already built inhouse (Stone, Exeter) will allow sensitive detection from the bandage within a few seconds to
minutes, depending on the need to measure small or large areas. Moreover, the change in chemical signature (due to ROS interaction with reporters) will provide us with the ability to specifically and sensitively determine the concentration of ROS in the wound environment over time (initially to be done with spiked sweat samples) and correlate it to wound healing. This can lead to personalized treatment for the patients and promote healthy living.
This project builds upon work undertaken at Exeter developing SESORS and nanostructures for disease detection and UQ in the development of gold nanostructures modified with Raman reporter molecules for the detection of ROS.
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