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Nanoencapsulation facilitated targeted drug delivery (QISU19SF)

Project Description

Nanoencapsulation of therapeutic agents in nanocarriers is an effective way for delivering ‘problematic’ drugs such as those with poorly aqueous solubility and biologics which are prone to degradation. The advantages of using such nanocarriers enables better targeting to the site of the disease and subsequently reduced dose requirements and systemic toxicity in comparison to non-targeted systemic delivery of the drug. A range of immerging processing technologies have been used for nanoencapsulation of drugs. This PhD project will compare the effects of different manufacturing methods on drug loading, drug targeting and throughput rate of production. The underpinning science behind these effects will be the core knowledge outputs from this project. This will enable development of a nanoencapsulation formulation strategy which will guide industrial applications and product development of nanoencapsulation based pharmaceutical products. The student will be exposed to and receive training on a wide range of nano-processing methods such as nanoprecipitation, electrohydrodynamic and microfluidic processes. Training on characterising the physicochemical properties and in vitro drug release behaviour of the nanocarriers will also be provided. The knowledge generated from the project will assist the rapid development of industrial applications of nanoencapsulation technologies.

For more information on the supervisor for this project, please go here:

Type of programme: PhD

Project start date: October 2019

Mode of study: Full time

Entry requirements: Acceptable first degree - Pharmaceutical, chemical and biomedical engineering or relevant degrees.
The standard minimum entry requirement is 2:1.

Funding Notes

This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at View Website.

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.


i) Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S. (2016) Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate, in Molecular Pharmaceutics 13 (1) pp. 25-39

ii) Codoni, D., Cowan, J., Bradley, J., O'Connell, M., McAuley, W., Qi, S. (2015) Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles, in International Journal of Pharmaceutics 496 (2) pp. 1015-1025

iii) Lung-Hsin Hung, Shia-Yen Teh, James Jester and Abraham P. Lee. PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches. Lab Chip, 2010, 10, 1820-1825

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