Imperial College London Featured PhD Programmes
Imperial College London Featured PhD Programmes
London School of Economics and Political Science Featured PhD Programmes

Nanomechanical alterations in Acute Type A Aortic Dissections

   Department of Mechanical, Aerospace & Materials Engineering

About the Project

Acute Type A aortic dissection (AAD), involves a splitting of the tunica media in the aortic wall. AAD is life-threatening and often occurs in young patients with no prior relevant medical history. Current clinical guidelines target patients for surgical repair when the aortic diameter exceeds 4.3-5.5 cm. However, this size cut-off is based on unreliable natural history data as many patients have acute pathology even in normal size aorta. Non-size dependent factors are key to understanding risk.

This PhD will test the hypothesis that that irrespective of aetiology and size, mechanical heterogeneity within the aortic wall determines risk and ultimate failure. The PhD project will involve accurate, quantitative measurements of the biomechanical, biochemical and ultrastructural properties of aortic tissue to help better define this pathological process and contribute ultimately to an AAD model of patient specific risk.

The PhD study will involve inter-disciplinary training in novel research methods including related to nanomechanics, biochemistry imaging methods and statistics.

The PhD project will be suitable for those with a strong background in biomedical engineering, biophysics, medical imaging or a related background. A Batchelors degree equivalent to a UK 2i (Second Class Upper Division) classification will be required as a minimum.

The successful candidate will join the LABB Group (Liverpool Aortic Biomechanics and Biochemistry Research Group),, a multidisciplinary group with expertise in aortic biomechanics, biochemistry and surgery. The LABB group has members from University of Liverpool, Royal University Liverpool Hospital and Liverpool Heart and Chest Hospital.

For any enquiries, please contact Dr Riaz Akhtar on: 

To apply for this opportunity, please visit: and click the 'Ready to apply? Apply now' button.

Funding Notes

This project is for self-funded students only, for example, through government-awarded scholarships. Tuition fees can be found on the following page: View Website
Bench fees will be £4000 per annum.

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