About the Project
Research in the Bode group focuses on the development of electron paramagnetic resonance (EPR) techniques through the combination of the synthesis of chemical models, EPR experiments, theory and simulations. Current EPR applications include a variety of biological and chemical systems.
When: September 2016.
Where: School of Chemistry, Biomedical Sciences Research Complex and Centre of Magnetic Resonance, University of St Andrews.
How: Fully funded (stipend and fees) for 3.5 years (EU/UK applicants).
We are seeking a highly motivated individual interested in an interdisciplinary PhD project in the laboratory of Dr Bela Bode. The project aims at extending the method of pulsed dipolar EPR spectroscopy which allows to measure nanometre distances between paramagnetic spin probes. The main target is the development of protocols for measuring distances between different types of spin probes. The project involves the preparation of (in)organic model compounds and their analysis. The gained insights will then be transferred to structural biology.
The EPR infrastructure available in St Andrews is truly world-leading (a Bruker EMX cw-X-Band, a Bruker E580 pulse X-Band, a Bruker E580 pulse X/Q-band hybrid and a home-built high power pulse W-band (HIPER) - all spectrometers having variable temperature accessories 4-300 K and all pulse spectrometers capable of high power ELDOR excitation).
Candidates should hold a scientific degree in chemistry, biology or physics and are expected to provide the contact details of two scientific referees. Previous experience in magnetic resonance or numerical simulations is desirable but not essential. Training will be provided as required.
More information is available at the Bode group website (http://chemistry.st-andrews.ac.uk/staff/beb/group/). Interested candidates should register their interest as soon as possible. Informal enquiries can be made to Dr Bela Bode ([Email Address Removed]).
Founded in the early 15th century, St Andrews is Scotland’s first university and the third oldest in the English speaking world. The University of St Andrews is a diverse and international community of over 9000, comprising students and staff of over 100 nationalities. It has 7,500 students, 6,000 of them undergraduates, and employs approximately 2,460 staff. The University is one of Europe’s most research intensive seats of learning. It is the top rated University in Scotland for teaching quality and student satisfaction and among the top rated in the UK for research.
Potential applicants are welcome to arrange to visit St Andrews at any time, although there will be a chemistry
postgraduate open day in St Andrews on the afternoon of Friday the 12th of February 2016.
Please see: http://www.st-andrews.ac.uk/chemistry/prospective/pg/ for the application procedure or e-mail
[Email Address Removed] for more information
References
(1) K. Ackermann, A. Giannoulis, D. B. Cordes, A. M. Z. Slawin, B. E. Bode, Assessing dimerisation degree and cooperativity in a biomimetic small-molecule model by pulsed EPR Chem. Commun. 2015, 51, 5257-5260.
(2) S. Valera, J. E. Taylor, D. S. B. Daniels, D. M. Dawson, K. S. Athukorala Arachchige, S. E. Ashbrook, A. M. Z. Slawin, B. E. Bode, A Modular Approach for the Synthesis of Nanometer-Sized Polynitroxide Multi-Spin Systems J. Org. Chem. 2014, 79, 8313–8323.
(3) S. Valera, B. E. Bode, Strategies for Synthesis of Yardsticks and Abaci for Nanometre Distance Measurements by Pulsed EPR Molecules 2014, 19, 20227-20256.
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