Proposed PhD project addresses the problem of the threat of viruses in the environment to the public. It is based on preliminary results in which specially designed nanoparticles have inhibited and eliminated viruses such as herpes simplex type 1 and 2, human papilloma virus, respiratory syncytial virus and dengue virus. These viruses exploit for the initial attachment and entry heparan sulfate proteoglycan that is naturally expressed on the cell surface. Here, we will test silver and gold nanoparticles that are capped with mercaptoundecane sulfonate groups, which mimics heparan sulfate. Nanoparticles will be prepared as a solid substance as well as applied on various materials using the sonochemical coating technique. In our group, we will examine their antiviral and virucidal effect on airborne infections (e.g. coxsackie virus, adenovirus, reovirus), water-borne infections (e.g. norovirus, rotavirus) and blood- and body fluid-borne infections (e.g. HIV, hepatitis B virus, Zika virus). During the postgraduate study, the student will learn how to work with cell cultures in biosafety level 3 settings among others how to determine replication and inhibition of various viruses, fluorescence immunochemistry techniques, qRT-PCR.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications