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Nanoparticles for elimination of viruses spreading through air, water and bodily fluids

  • Full or part time
    Dr J Weber
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Proposed PhD project addresses the problem of the threat of viruses in the environment to the public. It is based on preliminary results in which specially designed nanoparticles have inhibited and eliminated viruses such as herpes simplex type 1 and 2, human papilloma virus, respiratory syncytial virus and dengue virus. These viruses exploit for the initial attachment and entry heparan sulfate proteoglycan that is naturally expressed on the cell surface. Here, we will test silver and gold nanoparticles that are capped with mercaptoundecane sulfonate groups, which mimics heparan sulfate. Nanoparticles will be prepared as a solid substance as well as applied on various materials using the sonochemical coating technique. In our group, we will examine their antiviral and virucidal effect on airborne infections (e.g. coxsackie virus, adenovirus, reovirus), water-borne infections (e.g. norovirus, rotavirus) and blood- and body fluid-borne infections (e.g. HIV, hepatitis B virus, Zika virus). During the postgraduate study, the student will learn how to work with cell cultures in biosafety level 3 settings among others how to determine replication and inhibition of various viruses, fluorescence immunochemistry techniques, qRT-PCR.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Cagno V, et al. Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. 2018 Nat Mater. 17(2):195-203. doi: 10.1038/nmat5053. Epub 2017 Dec 18



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