About the Project
With atomic force microscopy (AFM) as a key tool, this project aims to investigate how these and other physical membrane properties affect assembly and membrane insertion of pore forming proteins such as bacterial toxins and bactericidal immune proteins. To understand the underlying biophysics, the student will make extensive use of model membranes with well-defined physical properties and characterise the membranes and membrane pore formation by nanoscale and single-molecule characterisation techniques.
STUDENT PROFILE: Applicants should have or be expecting to achieve a first or upper-second class honours degree (or equivalent) in physical sciences or biology. We are looking for candidates who are outstanding in their past experience in carrying out experimentally intricate research projects and in their academic performance in undergraduate and/or master level studies.
APPLICATION PROCEDURE: To apply, candidates are requested to follow the application procedure on https://www.ucl.ac.uk/physics-astronomy/study/phd and to send a PDF copy of their application to Prof. Bart Hoogenboom (firstname.lastname@example.org), who will also welcome informal inquiries on this project. Applications will be considered shortly after receipt of the above-mentioned PDF copy; with early applications strongly encouraged.
 Rudd-Schmidt et al., Nature Communications 2019
 Leung et al., eLife 2014
 Pang et al., Nature Communications 2019
 Parsons et al., Nature Communications 2019
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