Natural Product Synthesis

Project Summary

This PhD studentship will be focused on the biomimetic total synthesis of complex natural products. The chemical feasibility of proposed biosynthetic pathways towards biologically active diterpene structures will be investigated. As well as target-orientated research, the candidate will concurrently develop useful synthetic methodology based on these biomimetic reactions, which could be used to target other natural and non-natural targets. For recent examples of total syntheses completed by the Lawrence group, see the following publications:

1.        Chem. Sci. 2022, Advance Article (https://doi.org/10.1039/D1SC05801K)

2.        Org. Lett. 2021, 23, 3248–3252 (https://doi.org/10.1021/acs.orglett.1c00620)

3.        Nat. Chem. 2020, 12, 615–619 (https://doi.org/10.1038/s41557-020-0442-3)

Eligibility: Candidates should have, or be about to obtain, a 2.i or 1^st class degree in chemistry or a closely related discipline. Appointment of UK/EU/International candidates is allowable.

How to Apply: Applications consisting of a CV (including contact details for two referees) and a Cover Letter (describing your previous research experience and reasons for applying) should be emailed to Prof. Andrew Lawrence ([Email Address Removed]).

The position will remain open until filled (early applications are encouraged).

Start date: September 2022.

Equality and Diversity

The School of Chemistry holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. The University is a member of the Race Equality Charter and is a Stonewall Scotland Diversity Champion, actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment. See our University Initiatives website for further information. University Initiatives website: https://www.ed.ac.uk/equality-diversity/help-advice/family-friendly