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Prof Nick Selby
No more applications being accepted
Competition Funded PhD Project (Students Worldwide)
Nottingham
United Kingdom
Anatomy
Complementary Medicine
Molecular Biology
Neuroscience
Nutrition
Physiology
Physiotherapy
About the Project
Acute kidney injury (AKI) is a common consequence of acute illness impacting >13-million individuals worldwide each year. Despite this high prevalence and growing recognition of a prolonged symptom burden after recovery from AKI, little attention has been given to potential strategies to improve physical function in AKI patients. Reduced physical function is a substantial burden in those recovering from AKI, postulated to be due, at least in part, to losses of skeletal muscle mass and function during hospitalisation for AKI. Emerging evidence suggests that daily neuromuscular electrical stimulation (NMES) of the quadriceps can reduce losses of muscle mass and function in older cancer patients’ recovering from surgery. However, how this strategy may benefit AKI patients is not yet known. This PhD will use physiological assessments, molecular biology methods and novel imaging techniques to determine: i) the impact of in-hospital NMES on muscle mass and function in AKI patients during their hospital stay and ii) 3-months after hospital discharge; and iii) the potential of an emerging blood-based biomarker to assess muscle mass in AKI patients. Overall, this project will provide the successful candidate with varied skills and experience across the translational research pathway (i.e., bench-to-bedside).
Enquiries
Project Enquiries to [Email Address Removed] Faculty of Medicine & Health Science
Programme enquiries to [Email Address Removed]
To apply please refer to https://more.bham.ac.uk/mrc-aim/phd-opportunities/ for project opportunities and application form
Funding Notes
Competition Funded PhD Project (Students Worldwide) Closing date 10 January 2025 midday GMT
This is a fully funded Medical Research Council (MRC) studentship. Stipend and tuition fees are paid for 4 years at UKRI rates as well as there being a budget for project consumables, travel and a laptop to be purchased. The funder, UKRI, allows us to appoint up to 30% overseas students.
https://more.bham.ac.uk/mrc-aim/
References
1. Hoste EAJ, Kellum JA, Selby NM, et al. Global epidemiology and outcomes of acute kidney injury. Nat Rev Nephrol 2018; 14: 607-625.
2. Levin A, Tonelli M, Bonventre J, et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet 2017; 390: 1888-1917.
3. Lameire NH, Bagga A, Cruz D, et al. Acute kidney injury: an increasing global concern. Lancet 2013; 382: 170-179.
4. Noble RA, Lucas BJ, Selby NM. Long-Term Outcomes in Patients with Acute Kidney Injury. Clin J Am Soc Nephrol 2020; 15: 423-429.
5. Mayer KP, Ortiz-Soriano VM, Kalantar A, et al. Acute kidney injury contributes to worse physical and quality of life outcomes in survivors of critical illness. BMC Nephrology 2022; 23.
6. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16-31.
7. Hardy EJO, Inns TB, Hatt J, et al. The time course of disuse muscle atrophy of the lower limb in health and disease. J Cachexia Sarcopenia Muscle 2022; 13: 2616-2629.
8. Phillips BE, Hill DS, Atherton PJ. Regulation of muscle protein synthesis in humans. Curr Opin Clin Nutr Metab Care 2012; 15: 58-63.
9. Selby NM, Crowley L, Fluck RJ, et al. Use of electronic results reporting to diagnose and monitor AKI in hospitalized patients. Clin J Am Soc Nephrol 2012; 7: 533-540.
10. Fazzini B, Märkl T, Costas C, et al. The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Critical Care 2023; 27.
11. Hardy EJ, Hatt J, Doleman B, et al. Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial. Age Ageing 2022; 51.
12. Din USU, Brook MS, Selby A, et al. A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clin Nutr 2019; 38: 2071-2078.
13. Yang Y, Lv W, Zeng Y, et al. Bioelectrical impedance phase angle combined with physical function predicts pre-frailty in maintenance hemodialysis patients: a prospective study. BMC Nephrol 2024; 25: 243.
14. Ballew SH, Zhou L, Surapaneni A, et al. A Novel Creatinine Muscle Index Based on Creatinine Filtration: Associations with Frailty and Mortality. J Am Soc Nephrol 2023; 34: 495-504.
15. Mehta RL, Cerda J, Burdmann EA, et al. International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 2015; 385: 2616-2643.
16. Stewart J, Findlay G, Smith N, et al. NCEPOD report into Acute Kidney Injury: Adding Insult to Injury. National Confidential Enquiry into Patient Outcomes and Death, 2009.
17. NHS England: Acute Kidney Injury (AKI) Programme, www.thinkkidneys.nhs.uk. In, 2014
2. Levin A, Tonelli M, Bonventre J, et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet 2017; 390: 1888-1917.
3. Lameire NH, Bagga A, Cruz D, et al. Acute kidney injury: an increasing global concern. Lancet 2013; 382: 170-179.
4. Noble RA, Lucas BJ, Selby NM. Long-Term Outcomes in Patients with Acute Kidney Injury. Clin J Am Soc Nephrol 2020; 15: 423-429.
5. Mayer KP, Ortiz-Soriano VM, Kalantar A, et al. Acute kidney injury contributes to worse physical and quality of life outcomes in survivors of critical illness. BMC Nephrology 2022; 23.
6. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16-31.
7. Hardy EJO, Inns TB, Hatt J, et al. The time course of disuse muscle atrophy of the lower limb in health and disease. J Cachexia Sarcopenia Muscle 2022; 13: 2616-2629.
8. Phillips BE, Hill DS, Atherton PJ. Regulation of muscle protein synthesis in humans. Curr Opin Clin Nutr Metab Care 2012; 15: 58-63.
9. Selby NM, Crowley L, Fluck RJ, et al. Use of electronic results reporting to diagnose and monitor AKI in hospitalized patients. Clin J Am Soc Nephrol 2012; 7: 533-540.
10. Fazzini B, Märkl T, Costas C, et al. The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Critical Care 2023; 27.
11. Hardy EJ, Hatt J, Doleman B, et al. Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial. Age Ageing 2022; 51.
12. Din USU, Brook MS, Selby A, et al. A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clin Nutr 2019; 38: 2071-2078.
13. Yang Y, Lv W, Zeng Y, et al. Bioelectrical impedance phase angle combined with physical function predicts pre-frailty in maintenance hemodialysis patients: a prospective study. BMC Nephrol 2024; 25: 243.
14. Ballew SH, Zhou L, Surapaneni A, et al. A Novel Creatinine Muscle Index Based on Creatinine Filtration: Associations with Frailty and Mortality. J Am Soc Nephrol 2023; 34: 495-504.
15. Mehta RL, Cerda J, Burdmann EA, et al. International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 2015; 385: 2616-2643.
16. Stewart J, Findlay G, Smith N, et al. NCEPOD report into Acute Kidney Injury: Adding Insult to Injury. National Confidential Enquiry into Patient Outcomes and Death, 2009.
17. NHS England: Acute Kidney Injury (AKI) Programme, www.thinkkidneys.nhs.uk. In, 2014
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