About the Project
Three major areas are being pursued in our lab:
1. Matrix metalloproteinases in synaptic development
2. Cytoskeletal dynamics in motor neuron development and disease
3. Neurotrophic signaling in muscle physiology and disease
Using the simple and elegant Xenopus primary culture system, a variety of techniques, including live-cell time-lapse fluorescence microscopy, super-resolution microscopy, molecular biology, immunocytochemistry, and Western blotting will be applied to these experimental systems to gain understanding to the cellular and molecular mechanism of synaptic development. Our goal is to not only gain a mechanistic understanding of the molecular and cellular aspects of neuronal structure and function, but also provide insights into the cellular basis for neurological disorders.
Faculty information, funding opportunities and application deadlines: https://www.findaphd.com/phds/program/biomedical-research-hku-li-ka-shing-faculty-of-medicine/?i586p4119
Yeo HL*, Lim JY*, Fukami Y, Yuki N, and Lee CW# (2015) Using Xenopus tissue cultures for the study of myasthenia gravis pathogenesis. Developmental Biology 408(2): 244-51.
Lee CW, Vitriol EA, Shim S, Wise AL, Velayutham RP and Zheng JQ (2013) Dynamic localization of G-actin during membrane protrusion in neuronal motility. Current Biology 23(12):1046-56. (2012 Impact factor: 9.49)
Gu J^, Lee CW^, Fan Y^, Komols D, Tang X, Sun C, Yu K, Hartzell HC, Chen G, Bamburg JR and Zheng JQ (2010) ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Nature Neuroscience 13(10):1208-15. (^ Co-first authors) (2009 Impact factor: 14.35)
Lee CW, Han J, Bamburg JR, Han L, Lynn R and Zheng JQ (2009) Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking. Nature Neuroscience 12(7):848-56. (2008 Impact factor: 14.16)
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