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Neuronal activity in circuit development

  • Full or part time
  • Application Deadline
    Friday, February 07, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Mutations in synaptic genes are strongly associated with neurodevelopmental disorders. This project will focus on the role of NMDA receptors, many subunits of which have been implicated in autism and epilepsy.

Using a combination of conditional transgenic mouse lines and circuit-targeted in vivo delivery of viral / expression constructs, different NMDA receptor subunits will be manipulated in specific circuits. The impact on functional and structural circuit development, as well as neuronal excitability, will be addressed using electrophysiology, functional imaging, connectivity mapping and 3D imaging of cleared brain samples. The student will acquire expertise in many cutting edge techniques, and become part of the Centre for Developmental Neurobiology, a world leading department for developmental neuroscience, as well as an exceptionally supportive and collaborative environment.

Applicants must complete and submit an online admissions application, via the admissions portal by midnight (23:59 GMT), 7th February 2020.

On the ‘Choosing a programme’ page, please select ‘Research degrees’ and enter the keyword ‘Neurobiology’, then select ‘MRC Centre for Developmental Neurobiology Research MPhil/PhD (Full-time)’.

In the Funding section, please tick box 5 and include the following reference: LA-CDN-2020

Please note there is no need to complete the Research Proposal section in your application as the project has already been set.

You are welcome to email (supervisor) for more information regarding the project and studentship.

Only shortlisted applicants will be contacted; interviews are due to take place in late February 2020. The starting date is 1st October 2020.

For further information please visit:

• Centre for Developmental Neurobiology: https://devneuro.org/cdn/
• Centre for Neurodevelopmental Disorders: https://devneuro.org/cndd/
• Andreae lab webpage: https://devneuro.org/cdn/group-overview.php?groupID=84

Funding Notes

The fully funded studentships cover the following:

• Course fees (Home/EU rate)
• Stipend (approx. £21,450 per year)
• Contribution towards research costs, training and conference attendance.

Standard PhD entry requirements: Applicants should have a Bachelors degree with 2:1 honours (or Overseas equivalent). A 2:2 degree may be considered only where applicants also offer a Masters with Merit.

References

In your application, you will be asked to include:

• Academic Transcripts – where applicable, academic transcripts must be submitted with the online admissions application
• Details of your qualifications (you will need to attach copies)
• Details of previous employment
• A personal statement describing your interests and why you wish to apply for this project. Please include this as an attachment rather than using the text box.
• Academic References – admission applications require 1 reference, but 2 references are preferable. To add an additional reference, once you have submitted your application, please message your 2nd referee’s details to admission via King’s Apply Portal.

How good is research at King’s College London in Psychology, Psychiatry and Neuroscience?

FTE Category A staff submitted: 238.88

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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