The function of modulatory neurotransmitter systems such as serotonin, dopamine or acetylcholine are implicated in a wide range of brain diseases and are targeted by a wide range of therapeutic drugs. As well as modifying neuronal activity, these neurotransmitters can have powerful effects on the regulation of brain blood flow and the brain’s microvasculature. These vascular effects may play an important role in the trajectory of related diseases and possibly also in the efficacy of pharmacological treatments. They may also impact on our ability to interpret function brain imaging data in terms of underlying neuronal activity. PhD projects in this area will focus on a specific neurotransmitter system and use a range of in-vivo techniques to determine the modifying effects of that neurotransmitter of brain blood flow regulation.
Funding Notes
Self Funded or externally sponsored student only.
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