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New biorthogonal reactions on DNA

  • Full or part time
  • Application Deadline
    Thursday, February 21, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

New bioorthogonal reactions (chemical or enzymatic) in major or minor groove of DNA will be developed and studied for applications in DNA labelling, bioconjugations, and detection and imaging of epigenetic bases or DNA lesions.

How to apply:
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:

You can apply online via our application form


All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.


1. Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
2. Olszewska, A.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Chloroacetamide-linked nucleotides and DNA for cross-linking with peptides and proteins" Bioconjug. Chem. 2016, 27, 2089–2094.
3. Slavíčková, M.; Janoušková, M.; Šimonová, A.; Cahová, H.; Kambová, M.; Šanderová, H.; Krásný, L.; Hocek, M. "Turning off transcription with bacterial RNA polymerase through CuAAC click reactions of DNA containing 5-ethynyluracil" Chem. Eur. J. 2018, 24, 8311-8314.

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